Calcimycin

An ionophorous, polyether antibiotic from Streptomyces chartreusensis. It binds and transports CALCIUM and other divalent cations across membranes and uncouples oxidative phosphorylation while inhibiting ATPase of rat liver mitochondria. The substance is used mostly as a biochemical tool to study the role of divalent cations in various biological systems.

Also Known As:

A23187; A-23187; Antibiotic A23187; A 23187; A23187, Antibiotic; 4-Benzoxazolecarboxylic acid, 5- (methylamino)- 2- ((3,9,11- trimethyl- 8- (1- methyl- 2- oxo- 2- (1H- pyrrol- 2- yl)ethyl)- 1,7- dioxaspiro(5.5)undec- 2- yl)methyl)- , (6S- (6alpha(2S*,3S*),8beta(R*),9beta,11alpha))-

Pharmalogical Action Categories:

Anti-Bacterial Agents
Calcium Ionophores

Organic Chemicals: 140
- Lactones: 1590
  - Polyketides: 238
    - Polyether Polyketides: 22
      - Calcimycin: 793
- Ethers: 242
  - Cyclic Ethers: 12
    - Polyether Polyketides: 22
      - Calcimycin: 793
Heterocyclic Compounds: 207
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzoxazoles: 71
      - Calcimycin: 793
Polycyclic Compounds: 7
- Macrocyclic Compounds: 16
  - Polyketides: 238
    - Polyether Polyketides: 22
      - Calcimycin: 793
  - Cyclic Ethers: 12
    - Polyether Polyketides: 22
      - Calcimycin: 793

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Disease

Drug/Important Bio-Agent (IBA)